弓形虫病是由弓形虫寄生虫引起的感染。世界上三分之一的人口接触过这种寄生虫。在墨西哥,普通人群的患病率在15%至50%之间,高危妊娠女性的患病率为34.9%.在怀孕期间,感染发生率最高发生在妊娠晚期,胎儿损害与胎龄成反比。母体激素在免疫反应中起着基本作用。很少有研究,有争议的结果,关于怀孕期间增加的激素水平及其与弓形虫感染动力学的关系。目的是确定17-β雌二醇的血清水平,催乳素,和黄体酮,以及他们与反T.妊娠中的弓形虫抗体动力学。对52名孕妇进行了研究。使用了社会人口统计学和临床方面的问卷。之后,每三个月通过静脉穿刺收集10mL静脉血。17-β雌二醇的浓度,黄体酮,测量催乳素,使用ELISA方法。此外,抗弓形虫IgG和IgM抗体也在第一,第二,和第三个三个月。抗弓形虫IgG抗体的患病率在妊娠早期和中期为26.92%,在妊娠晚期为32.7%。在血清呈阳性的女性中,17-β雌二醇在妊娠的第二和第三个三个月增加。在这些妇女的妊娠晚期,孕酮显着增加p<0.039,而催乳素在妊娠中期增加,统计学意义为p<0.021。此外,17-β雌二醇,黄体酮,和催乳素与妊娠期间弓形虫感染有关。有必要进行新的研究,以阐明怀孕期间与这些激素相关的免疫反应的特定机制。
Toxoplasmosis is an infection caused by the parasite Toxoplasma gondii. One-third of the world\'s population has come into contact with this parasite. In Mexico, the prevalence is between 15% and 50% in the general population and 34.9% in women with high-risk pregnancies. In pregnancy, the highest incidence of infection occurs in the third trimester and fetal damage is inversely proportional to gestational age. Maternal hormones play a fundamental role in the immune response. There are very few studies, with controversial results, on the levels of increased hormones and their relationship to the kinetics of T. gondii infections during pregnancy. The aim was to determine the serum levels of 17-β estradiol, prolactin, and progesterone, and their association with anti-T. gondii antibodies\' kinetics in pregnancy. Fifty-two pregnant patients were studied. A questionnaire with sociodemographic and clinical aspects was used. Afterward, 10 mL of venous blood was collected by venipuncture every trimester. The concentrations of 17-β estradiol, progesterone, and prolactin were measured, using the ELISA method. In addition, anti-Toxoplasma IgG and IgM antibodies were also determined in the first, second, and third trimester. The prevalence of anti-Toxoplasma IgG antibodies was 26.92% in the first and second trimester and 32.7% in the third trimester. In seropositive women, 17-β estradiol increased in the second and third trimesters of pregnancy. Progesterone increased significantly p < 0.039 in the third trimester in these women, while prolactin increased in the second trimester with a statistical significance of p < 0.021. In addition, 17-β estradiol, progesterone, and prolactin are associated with T. gondii infection during pregnancy. New studies are necessary to clarify the specific mechanisms of immune response related to these hormones during pregnancy.